Antihistamine intermediate

4-Chloro Benzhydrol

Reduced form of 4-chloro benzophenone — the benzylic alcohol coupled with piperazine in the cetirizine route.

CAS No.: 119-56-2
Molecular formula: C₁₃H₁₁ClO
Mol. weight: 218.68 g/mol
Appearance: White crystalline powder
API target: Cetirizine dihydrochloride (CAS 83881-52-1)

Description

Obtained by selective reduction of 4-chloro benzophenone, 4-chloro benzhydrol carries the activated benzylic hydroxyl that is converted to the benzhydryl chloride and alkylated onto piperazine to deliver the chiral pharmacophore of cetirizine and levocetirizine.

Applications

Cetirizine and levocetirizine synthesis
Building block for benzhydryl ethers

Other products

4-Chloro Benzophenone

C₁₃H₉ClO

4-Chloro Benzhydryl Piperazine

C₁₇H₁₉ClN₂

(R)-(4-Chlorophenyl)(phenyl)methanamine

C₁₃H₁₂ClN

N,N-Bis(2-chloroethyl)-4-methylbenzenesulfonamide

C₁₁H₁₅Cl₂NO₂S