Antihistamine intermediate

2-(Piperidin-4-yl)-1H-benzimidazole

Piperidinyl benzimidazole — the heterocyclic core of the second-generation antihistamine bilastine.

CAS No.: 38385-95-4
Molecular formula: C₁₂H₁₅N₃
Mol. weight: 201.27 g/mol
Appearance: Off-white crystalline solid
API target: Bilastine (CAS 202189-78-4)

Description

The piperidine nitrogen is N-alkylated with the ethoxyethyl side chain to deliver the advanced bilastine intermediate. The molecule's H1-receptor selectivity is set by the benzimidazole–piperidine pharmacophore.

Applications

Bilastine synthesis

Other products

4-Chloro Benzophenone

C₁₃H₉ClO

4-Chloro Benzhydrol

C₁₃H₁₁ClO

4-Chloro Benzhydryl Piperazine

C₁₇H₁₉ClN₂

(R)-(4-Chlorophenyl)(phenyl)methanamine

C₁₃H₁₂ClN