COX-2 inhibitor intermediate

4-(Methylsulfonyl)phenyl Acetic Acid

Methylsulfonyl phenyl acetic acid — the sulfonyl-aryl fragment of the selective COX-2 inhibitor etoricoxib.

CAS No.: 90536-66-6
Molecular formula: C₉H₁₀O₄S
Mol. weight: 214.24 g/mol
Appearance: White crystalline powder
API target: Etoricoxib (CAS 202409-33-4)

Description

The acetic acid side chain is condensed with an appropriate 2,2'-bipyridine ketone to install the central pyridine ring of etoricoxib, while the methylsulfonyl group remains as the COX-2 selectivity-determining pharmacophore.

Applications

Etoricoxib manufacture

Other products

4-Chloro Benzophenone

C₁₃H₉ClO

4-Chloro Benzhydrol

C₁₃H₁₁ClO

4-Chloro Benzhydryl Piperazine

C₁₇H₁₉ClN₂

(R)-(4-Chlorophenyl)(phenyl)methanamine

C₁₃H₁₂ClN