Antihistamine intermediate

Benzeneacetic Acid, 4-(2-Chloroethyl)-α,α-dimethyl-

α,α-Dimethyl phenyl acetic acid with a chloroethyl side chain — the carboxylic acid arm of bilastine.

CAS No.: 2199440-16-7
Molecular formula: C₁₂H₁₅ClO₂
Mol. weight: 226.70 g/mol
Appearance: White to off-white crystalline solid
API target: Bilastine (CAS 202189-78-4)

Description

Couples through its chloroethyl terminus with the N-ethoxyethyl benzimidazole-piperidine fragment to assemble bilastine in a single N-alkylation step. The α,α-dimethyl quaternary centre is critical for the non-sedating profile of the API.

Applications

Bilastine final-step alkylation

Other products

4-Chloro Benzophenone

C₁₃H₉ClO

4-Chloro Benzhydrol

C₁₃H₁₁ClO

4-Chloro Benzhydryl Piperazine

C₁₇H₁₉ClN₂

(R)-(4-Chlorophenyl)(phenyl)methanamine

C₁₃H₁₂ClN