Alpha-1 blocker intermediate

Indoline

2,3-Dihydro-1H-indole

Saturated indoline scaffold — the bicyclic core of silodosin and several CNS molecules.

CAS No.: 496-15-1
Molecular formula: C₈H₉N
Mol. weight: 119.16 g/mol
Appearance: Pale yellow liquid
API target: Silodosin (CAS 160970-54-7)

Description

Indoline (2,3-dihydroindole) is the saturated relative of indole. In the silodosin synthesis it is functionalised at C-5 with a 2-hydroxypropyl chain that is later resolved to install the chiral aminopropyl arm responsible for α1A selectivity.

Applications

Silodosin synthesis
Building block for CNS and α-blocker APIs

Other products

4-Chloro Benzophenone

C₁₃H₉ClO

4-Chloro Benzhydrol

C₁₃H₁₁ClO

4-Chloro Benzhydryl Piperazine

C₁₇H₁₉ClN₂

(R)-(4-Chlorophenyl)(phenyl)methanamine

C₁₃H₁₂ClN