Alpha-1 blocker intermediate

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl Methanesulfonate

Trifluoroethoxy phenoxy ethyl mesylate — the aryl-ether alkylating agent in silodosin.

CAS No.: 160969-03-9
Molecular formula: C₁₁H₁₃F₃O₅S
Mol. weight: 314.28 g/mol
Appearance: Off-white solid
API target: Silodosin (CAS 160970-54-7)

Description

This mesylate is used to N-alkylate the chiral indoline-aminopropyl intermediate of silodosin, installing the 2-(trifluoroethoxy)phenoxy ethyl side chain that delivers the selectivity for the α1A-adrenoceptor.

Applications

Silodosin manufacture

Other products

4-Chloro Benzophenone

C₁₃H₉ClO

4-Chloro Benzhydrol

C₁₃H₁₁ClO

4-Chloro Benzhydryl Piperazine

C₁₇H₁₉ClN₂

(R)-(4-Chlorophenyl)(phenyl)methanamine

C₁₃H₁₂ClN